Introduction
The information listed below is obtained from in game. You can find this information by looking at your “Access Info” menu. The below information was compiled in order to have a quick look at how to farm the Python in the First Descendant versus having to navigate the many menus in game.
The abbreviation AMO# stands for Amorphous number. You will need to obtain an amorphous material first. You can do this by farming the “AMO Location” below. Next, go to the AMO Open Location in order to open the amorphous for a chance at receiving the material you’re looking for. The Drop % is the drop percentage chance you’ll have at receiving the material when you open the amorphous.
Any mission that requires Hard mode is highlighted in red and noted with a (H). Normal mode missions are noted with a (N). The locations are listed by zone first and then the area within that zone.
You only need to obtain one of each of the materials in order to craft the weapon. Once you have them you can make your way to Anais in Albion to craft your new ultimate weapon.
You can see where to farm all of the other Ultimate Weapons in the game by checking this guide!
How to Farm the Python
| Material | AMO # | AMO Location | AMO Open Location | Drop % |
|---|---|---|---|---|
| Python Polymer Syncytium | 29 | (N) Agna Desert The Asylum | (N) Devourer Colossus | 6% |
| Python Polymer Syncytium | 44AA | (N) Hagios Old Mystery | (N) Swamp Walker Colossus | 15% |
| Python Polymer Syncytium | 54 | (H) Kingston Fallen Theatre Outpost | (H) Kingston Grand Square Reactor | 32% |
| Python Polymer Syncytium | 88 | (H) Agna Desert Vermilion Waste Outpost | (H) Agna Desert Vermilion Waste Void Reactor | 32% |
| Python Nano Tube | 7 | (N) Sterile Land Repository Outpost | (N) Sterile Land Repository Void Reactor | 6% |
| Python Nano Tube | 39 | (N) White-Night Gulch Block Kuiper Mining | (N) Pyromaniac Colossus | 15% |
| Python Nano Tube | 59 | (H) Kingston Slumber Valley | (H) Executioner Colossus | 32% |
| Python Nano Tube | 102 | (H) White-Night Gulch Hatchery Outpost | (H) White-Night Gulch Hatchery Void Reactor | 32% |
| Python Synthetic Fiber | 5 | (N) Kingston Kingston Defense | (N) Grave Walker Colossus | 38% |
| Python Synthetic Fiber | 9 | (N) Sterile Land The Forgottense | (N) Stunning Beauty Colossus | 38% |
| Python Synthetic Fiber | 96 | (H) Agna Desert Caligo Ossuary | (H) Swamp Walker Colossus | 32% |
| Python Synthetic Fiber | 105 | (H) Hagios The Haven | (H) Obstructer Colossus | 32% |
| Python Blueprint | 25 | (N) Echo Swamp Defend Albion Resources | (N) Dead Bride Colossus | 6% |
| Python Blueprint | 63 | (H) Sterile Land The Repository Outpost | (H) Sterile Land The Repository Void Reactor | 32% |
| Python Blueprint | 71AA | (H) Vespers The Lumber Yard Outpost | (H) Vespers The Ruins Void Reactor | 32% |
| Python Blueprint | 123 | (H) Fortress Defense Line Outpost | (H) Molten Fortress Colossus | 32% |
You can see where to farm all of the other Ultimate Weapons in the game by checking this guide!